Fri Nov 18 2022

66 articles - From Friday Nov 11 2022 to Friday Nov 18 2022

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Lancet

Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial.

Interpretation An intensive treatment strategy of rapid up-titration of guideline-directed medication and close follow-up after an acute heart failure admission was readily accepted by patients because it reduced symptoms, improved quality of life, and reduced the risk of 180-day all-cause death or heart failure readmission compared with usual care. Funding Roche Diagnostics.

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Meta-analysis

meta-analyses and systematic reviews

Lancet

Balloon catheters versus vaginal prostaglandins for labour induction (CPI Collaborative): an individual participant data meta-analysis of randomised controlled trials.

Interpretation In induction of labour, balloon catheters and vaginal prostaglandins have comparable caesarean delivery rates and maternal safety profiles, but balloon catheters lead to fewer adverse perinatal events. Funding Australian National Health and Medical Research Council and Monash Health Emerging Researcher Fellowship.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Monoclonal Antibodies for Treatment of SARS-CoV-2 Infection During Pregnancy : A Cohort Study.

In pregnant persons with mild to moderate COVID-19, adverse events after mAb treatment were mild and rare. There was no difference in obstetric-associated safety outcomes between mAb treatment and no treatment among persons who delivered. There was no difference in 28-day COVID-19-associated outcomes and non-COVID-19-related hospital admissions for mAb treatment compared with no mAb treatment in a propensity score-matched cohort. Primary funding source No funding was received for this study.

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Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis : A Randomized Controlled Trial.

Both TAR and AF improve MOXFQ-W/S and had similar clinical scores and number of harms. Total ankle replacement had greater wound healing complications and nerve injuries, whereas AF had greater thromboembolism and nonunion, with a symptomatic nonunion rate of 7%. Primary funding source National Institute for Health and Care Research Heath Technology Assessment Programme.

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Lancet

Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial.

Interpretation In patients with resistant hypertension, aprocitentan was well tolerated and superior to placebo in lowering blood pressure at week 4 with a sustained effect at week 40. Funding Idorsia Pharmaceuticals and Janssen Biotech.

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Evaluation of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): an open-label, multicentre, randomised, non-inferiority trial.

Interpretation Both bedaquiline-containing regimens, a 9-month oral regimen and a 6-month regimen with 8 weeks of second-line injectable, had superior efficacy compared with a 9-month injectable-containing regimen, with fewer cases of hearing loss. Funding USAID and Janssen Research & Development.

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Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial.

These results indicate that low-dose low-molecular-weight heparin for thromboprophylaxis during pregnancy is the appropriate dose for the prevention of pregnancy-related recurrent venous thromboembolism. Funding French Ministry of Health, Health Research Board Ireland, GSK/Aspen, and Pfizer.

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LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial.

This finding, together with the pharmacodynamic findings of robust reductions in glucose and bodyweight, provides support for phase 2 development. Funding Eli Lilly and Company.

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Q-122 as a novel, non-hormonal, oral treatment for vasomotor symptoms in women taking tamoxifen or an aromatase inhibitor after breast cancer: a phase 2, randomised, double-blind, placebo-controlled trial.

Our results support the conduct of larger and longer studies of Q-122, with potential use extending to postmenopausal women who require an alternative to menopausal hormone therapy. Funding QUE Oncology.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Intern Med

When States Step Up: California and the Case for State-Led Insulin Manufacturing.

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Lancet

Offline: No dark sarcasm in the classroom.

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Why is health literacy failing so many?

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N Engl J Med

Audio Interview: The FDA and Covid-19 Vaccines.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Intern Med

A Dubious Discharge.

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Affirmative Action Bans and Enrollment of Students From Underrepresented Racial and Ethnic Groups in U.S. Public Medical Schools.

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Affirmative Action Bans and Enrollment of Students From Underrepresented Racial and Ethnic Groups in U.S. Public Medical Schools.

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Ankle Osteoarthritis: Successful Completion of a Challenging Clinical Trial Comparing Surgical Treatments.

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Annals for Educators - November 2022.

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Annals for Hospitalists - November 2022.

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Changes in Health Care Spending, Use, and Clinical Outcomes After Nonfatal Firearm Injuries Among Survivors and Family Members.

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How Do Implicit Bias and Stereotype Threat Affect Mental Health Care for a Student of Color?

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Late in the Afternoon.

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lost monarchs.

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Risks for Anaphylaxis With Intravenous Iron Formulations.

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Risks for Anaphylaxis With Intravenous Iron Formulations.

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Summary for Patients: Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis.

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Web Exclusive. Annals Consult Guys - Medical Emergency at 37,000 Feet: Is There a Medical Professional on Board?

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Web Exclusive. Annals for Hospitalists Inpatient Notes - Managing Alcohol Withdrawal Syndrome in the Hospital Setting-A Call for Research.

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Web Exclusive. Annals On Call - Underuse of Thiamine in Patients With Alcohol Use Disorder in the Intensive Care Unit.

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Lancet

A revolution in the management of multidrug-resistant tuberculosis.

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COVID-19 and other adult vaccines can drive global disease prevention.

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Delivering evidence to prevent recurrent venous thromboembolism in pregnancy.

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Endothelin antagonists and the quest for a new therapeutic option in resistant hypertension.

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Gary Barker: advocate for men's health and gender equality.

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Health-care challenges for new Brazilian President.

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Induction of labour: first, do no harm.

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Peter Boyle.

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Phase 2 data on a new treatment for hot flushes in women with breast cancer.

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Smartwatch electrocardiogram records ST depression, premature ventricular complexes, and ventricular fibrillation.

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UK-India trade deal could "jeopardise" generic medicines.

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US Government agencies consider action on PFAS.

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N Engl J Med

A Good Catch.

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Case 35-2022: A 60-Year-Old Man with Progressive Dyspnea, Neck Swelling, and a Lung Mass.

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Health Care Access on the Line - Audio-Only Visits and Digitally Inclusive Care.

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IARC Perspective on Oral Cancer Prevention.

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Informing the Debate about Telemedicine Reimbursement - What Do We Need to Know?

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Iron Deposition from a Retained Intraocular Foreign Body.

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Mercury Poisoning.

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Understanding the Key to Outbreak Control - Sudan Virus Disease in Uganda.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

ACT-A: half empty or half full?

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Nomination for Nobel Prizes: is it possible for Indian scientists?

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On the politics and ethics of strike action by health professionals.

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WHO Living Guidelines on antivirals for COVID-19 are evidence-based.

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World Health Forum 2022 at Tsinghua University.

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N Engl J Med

Children with Acute Hepatitis of Unknown Cause.

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Children with Acute Hepatitis of Unknown Cause.

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Children with Acute Hepatitis of Unknown Cause.

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Children with Acute Hepatitis of Unknown Cause. Reply.

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Children with Acute Hepatitis of Unknown Cause. Reply.

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European Haplotype of Echinococcus multilocularis in the United States.

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In Vitro Efficacy of Antiviral Agents against Omicron Subvariant BA.4.6.

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More on Omicron Infections in Children.

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More on Omicron Infections in Children. Reply.

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Personality Disorders.

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Personality Disorders.

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Personality Disorders. Reply.

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